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Related Concept Videos

Quality Assurance01:19

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
Data Validation01:03

Data Validation

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
Quality Control01:05

Quality Control

Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...

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Related Experiment Video

Updated: May 22, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

Towards valid and reusable reference alignments - ten basic quality checks for ontology alignments and their

Elena Beisswanger1, Udo Hahn

  • 1Jena University Language and Information Engineering (JULIE) Lab, Friedrich-Schiller-Universität Jena, Jena, Germany. elena.beisswanger@uni-jena.de.

Journal of Biomedical Semantics
|May 1, 2012
PubMed
Summary

This study introduces quality checks for ontology alignments, ensuring their validity and reusability. These checks are crucial for evaluating automated alignment systems and improving data integration across scientific domains.

Related Experiment Videos

Last Updated: May 22, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

Area of Science:

  • Bioinformatics
  • Data Science
  • Ontology Engineering

Background:

  • Ontology alignment identifies relationships between entities in different ontologies.
  • Manual or automated systems create alignments, with automated systems using diverse relation detection methods.
  • Reference alignments, typically manually created, are used to evaluate these systems.

Purpose of the Study:

  • To derive requirements for valid and reusable reference alignments based on practical experience.
  • To develop and apply simple quality checks to assess the validity and reusability of reference alignments.
  • To evaluate standard and recent cross-domain reference alignments using the proposed quality checks.

Main Methods:

  • Analysis of existing reference alignments to identify common issues and derive quality requirements.
  • Development of a set of quality checks based on the derived requirements.
  • Application of these quality checks to a biomedical reference alignment (OAEI Anatomy track) and two multi-domain datasets.

Main Results:

  • The proposed quality checks provide a systematic approach to assess reference alignment quality.
  • The evaluation revealed potential issues in validity and reusability in the tested reference alignments.
  • The checks are applicable across different domains, including anatomy and biology.

Conclusions:

  • Implementing these quality checks enhances the reliability of reference alignments used for evaluating ontology alignment systems.
  • Ensuring alignment validity and reusability is critical for accurate system comparison and effective data integration.
  • The developed quality checks contribute to the standardization and improvement of ontology alignment evaluation methodologies.