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Related Experiment Video

Updated: May 22, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Multifocal choroid plexus papilloma: a case report.

Martin Scholsem1, Felix Scholtes, Pierre A Robe

  • 1Department of Neurosurgery, Westmead Hospital, Darcy Road, Westmead, Australia. martin.scholsem@yahoo.com

Clinical Neuropathology
|May 1, 2012
PubMed
Summary

Multiple synchronous choroid plexus papillomas (CPPs) are rare. This case highlights three benign CPPs, suggesting synchronous origin over metastasis.

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Area of Science:

  • Neuro-oncology
  • Pathology

Background:

  • Multiple choroid plexus papillomas (CPPs) are uncommon, often linked to villous hypertrophy or metastatic spread.
  • Synchronous multifocal CPPs are exceptionally rare in medical literature.

Observation:

  • A 59-year-old female presented with three synchronous choroid plexus papillomas, initially noted on imaging six years prior.
  • Surgical resection revealed mucus-producing CPPs in all three lesions.
  • One of the three tumors exhibited minor atypia; however, no p53 or hSNF5/INI1 mutations or polyoma virus infections were detected.

Findings:

  • The simultaneous occurrence and benign histological features of the three tumors strongly indicate a synchronous origin.
  • The absence of specific genetic mutations or viral markers complicates etiological determination.

Implications:

  • This case underscores the importance of distinguishing synchronous CPPs from metastatic disease, particularly given their benign histology.
  • Further research is needed to elucidate the underlying mechanisms driving multifocal choroid plexus papilloma development.