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Published on: August 22, 2017
Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects
Hye Duck Choi1, Hye Jung Lee, Sang Hun Lee
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.
Background:
Cilostazol is frequently used to treat and prevent thrombosis in Korean patients.
Patients And Methods:
We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t(1/2), and C(max) were 12,100 ± 4,880 ng×h/ ml, 11.1 ± 4.4 hours, and 827 ± 361 ng/ml, respectively.
Results:
ALT was positively correlated with age and C(max) was positively correlated with AUC, but negatively correlated with body weight.
Conclusion:
We suggest that the unique pharmacokinetic parameters and interrelationship can help to understand the pharmacokinetics of cilostazol in Korean subjects.
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