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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Nursing Evaluation01:15

Nursing Evaluation

The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
Section...
Purpose of Health Records II01:19

Purpose of Health Records II

Health records serve various essential purposes in the healthcare system. Here are some key purposes:
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...
National Nursing Organizations II01:30

National Nursing Organizations II

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Related Experiment Video

Updated: May 22, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

[The EUCORE registry: objectives and general results].

Emilia Cercenado1, Jerónimo Pachón

  • 1Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, España. ecercenado@terra.es

Enfermedades Infecciosas Y Microbiologia Clinica
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Daptomycin effectively treats severe Gram-positive infections, showing a 78.4% clinical success rate in a European registry study. While generally safe, reduced efficacy was noted in patients with renal failure.

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Last Updated: May 22, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

Area of Science:

  • Pharmacology and Infectious Diseases
  • Clinical Pharmacy and Therapeutics
  • Post-marketing Surveillance

Context:

  • The European Cubicin Outcomes Registry and Experience (EUCORE) database collected retrospective data on daptomycin use across European institutions.
  • This analysis focuses on 726 patients from Spanish institutions treated between January 2006 and March 2010.
  • A significant proportion of patients were elderly (48.6%), male (66%), and had comorbidities (70%).

Purpose:

  • To evaluate the clinical outcomes and safety profile of daptomycin in a real-world patient population.
  • To analyze daptomycin's effectiveness in treating various severe Gram-positive bacterial infections.
  • To identify factors influencing daptomycin efficacy, such as administration setting and patient renal function.

Summary:

  • Daptomycin was administered for diverse infections, including bacteremia (32.51%), skin/soft tissue infections (31.4%), and endocarditis (14.33%), primarily caused by Staphylococcus aureus and coagulase-negative staphylococci.
  • The overall clinical success rate was 78.4%, with higher efficacy (81.5%) when used as first-line therapy versus rescue therapy (77.6%).
  • Adverse events included decreased creatinine clearance (8.7%) and elevated creatine kinase levels in some patients, with lower efficacy observed in those with renal failure.

Impact:

  • Daptomycin demonstrates safety and effectiveness as an antimicrobial agent for severe Gram-positive infections.
  • Findings highlight the importance of considering renal function when prescribing daptomycin.
  • The study contributes valuable post-marketing data on daptomycin's real-world clinical utility.