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[Safety and efficacy of daptomycin therapy in older adults with pluripathology]

Jorge Parra-Ruiz1, José Hernández-Quero

  • 1Unidad de Enfermedades Infecciosas, Unidad de Gestión Clínica de Medicina Interna y Enfermedades Infecciosas, Hospital Universitario San Cecilio, Granada, España.

Enfermedades Infecciosas Y Microbiologia Clinica
|May 1, 2012
PubMed

Insights

Daptomycin is effective and safe for older adults with serious Gram-positive bacterial infections. Data from the Cubicin Outcomes Registry and Experience (CORE) and EUCORE registries support its use in patients over 65.

Area of Science:

  • Infectious Diseases
  • Geriatrics
  • Pharmacology

Context:

  • Serious Gram-positive bacterial infections are a significant cause of illness and death in older adults.
  • Daptomycin is frequently used in this demographic, but specific efficacy and safety data are limited.
  • Older adults (>65 years) represent over 50% of daptomycin recipients.

Purpose:

  • To evaluate the efficacy and safety of daptomycin in patients aged 65 years and older with serious Gram-positive bacterial infections.
  • To analyze post-marketing clinical data from real-world daptomycin use in an elderly population.

Summary:

  • Analysis of data from the Cubicin Outcomes Registry and Experience (CORE) and EUCORE registries included patients >65 years old treated with daptomycin.
  • Efficacy and safety outcomes in older patients were comparable to those observed in younger patients.
  • Daptomycin demonstrated similar rates of efficacy and safety in elderly patients.

Impact:

  • Suggests daptomycin is a valuable therapeutic option for older patients facing serious Gram-positive infections.
  • Provides evidence to support the use of daptomycin in geriatric populations.
  • Addresses a gap in clinical data regarding daptomycin's use in older adults.

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