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Updated: May 22, 2026
05:17
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
K C Nicolaou1, Roman A Valiulin, Jonathan K Pokorski
1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. kcn@scripps.edu
Bioorganic & Medicinal Chemistry Letters
|May 1, 2012
Abstract:
A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.
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