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Related Concept Videos

Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Secretory Phase01:19

Secretory Phase

The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

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Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

Defective endometrial receptivity.

Ariel Revel1

  • 1Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel. arielr2@hadassah.org.il

Fertility and Sterility
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Understanding endometrial receptivity is crucial for improving IVF success. This review details factors affecting uterine receptivity and molecular markers, offering insights into enhancing embryo implantation and pregnancy rates.

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Last Updated: May 22, 2026

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Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Area of Science:

  • Reproductive biology
  • Gynecology
  • Embryology

Background:

  • The endometrium plays a critical role in embryo implantation during a specific window of the menstrual cycle.
  • Assisted reproductive techniques (ART) are limited by challenges in improving embryo implantation rates.
  • Successful embryo implantation depends on the cross-talk between the embryo and a receptive endometrium.

Purpose of the Study:

  • To review factors contributing to defective endometrial receptivity.
  • To discuss contemporary investigations into molecular markers of endometrial receptivity.
  • To highlight the importance of understanding the uterine-embryo interface for improving IVF outcomes.

Main Methods:

  • Review of literature on endometrial receptivity.
  • Discussion of diagnostic tools such as sonography, hysteroscopy, and endometrial biopsy.
  • Exploration of anatomical and functional markers of endometrial receptivity.

Main Results:

  • Identified factors causing defective endometrial receptivity include uterine polyps, septa, leiomyomata, adhesions, thin endometrium, endometriosis, and hydrosalpinx.
  • Contemporary investigations focus on molecular markers to assess endometrial receptivity.
  • Improved understanding of the uterine environment is key to enhancing implantation.

Conclusions:

  • Defective endometrial receptivity is a significant barrier in achieving successful pregnancies with ART.
  • Comprehensive evaluation of the uterine cavity and molecular markers can identify causes of implantation failure.
  • Focusing on improving endometrial receptivity is essential for increasing pregnancy rates in IVF.