Related Experiment Video
Updated: May 22, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
The role of biomarkers in cancer clinical trials
1Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Mary.Reid@RoswellPark.org
Objectives:
To review strategies to incorporate biomarkers into screening studies, and prevention and therapeutic clinical trials.
Data Sources:
Published research articles.
Conclusion:
The incorporation of biomarkers into cancer clinical trials has been an important advancement in the last two decades of cancer research and has been critical to increasing our understanding of cancer across the spectrum from early lesions to frank cancers. While the incorporation of biomarkers into studies may increase the significance of the results, they also increase cost and a burden on research subjects.
Implications For Nursing Practice:
It is important for nurses to have an understanding of both the science and the implications of the biomarkers.
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