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Updated: May 22, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
[Keloid scars on black skin: myth or reality]
1Service de chirurgie plastique reconstructrice et esthétique, chirurgie de la main et brûlologie, CHU de Treichville, 01 BP V 3 Abidjan 01, Côte d'Ivoire. allahkchristophe@yahoo.fr
Keloid scars, characterized by excessive collagen, frequently recur, particularly in individuals with darker skin tones. This study analyzed 149 keloid cases, highlighting treatment outcomes and prevalence in diverse populations.
Area of Science:
- Dermatology
- Pathology
- Surgical Oncology
Background:
- Keloid scars result from excessive type I collagen accumulation in the dermis.
- They exhibit high morbidity due to frequent and unpredictable recurrences.
- Keloids disproportionately affect individuals of Black African and Asian descent.
Purpose of the Study:
- To analyze treatment outcomes for 149 keloid cases.
- To discuss the clinical presentation and management of keloids, especially in darker-skinned individuals.
Main Methods:
- Retrospective analysis of 98 patients treated for 149 keloid tumors between 1990 and 2011.
- Evaluation of patient demographics, etiologies, scar locations, and presenting symptoms.
- Surgical interventions included total excision (TE) with skin grafting and intrakeloid excision (IKE) with intra-lesional steroids.
Main Results:
- The study included 78 adults and 20 children, with a higher prevalence in women (65.3%) and Black individuals (96%).
- Trauma was the leading cause (63.1%), with keloids most commonly occurring on the head (56.4%) and ears (25.5%).
- Recurrence rates were high (100%), influenced by complications, with aesthetic concerns and pain being primary reasons for consultation.
Conclusions:
- Keloids are biologically heterogeneous, with higher prevalence in darker-skinned populations.
- Treatment outcomes are still under evaluation.
- The most effective prevention strategy is avoiding scar formation altogether.
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