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Updated: May 22, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
06:33

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Published on: December 9, 2014

[Periconceptional toxoplasmic seroconversion: about 79 cases].

C Garabedian1, J Le Goarant, L Delhaes

  • 1Clinique d'obstétrique, pôle Femme-Mère-Nouveau-né, maternité Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France. charles.garabedian@gmail.com

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|May 1, 2012
PubMed
Summary
This summary is machine-generated.

Periconceptional toxoplasmosis infection in pregnant women resulted in a 3.8% congenital infection rate, with a high miscarriage rate of 66% in infected fetuses. Regular ultrasound monitoring is crucial for managing fetal outcomes.

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Published on: March 12, 2015

Area of Science:

  • Medical Parasitology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Toxoplasmosis, a zoonotic disease caused by *Toxoplasma gondii*, poses significant risks to fetal development when contracted during pregnancy.
  • France has implemented a maternal screening program for toxoplasmosis since 1978.
  • Evaluating fetal outcomes following periconceptional maternal infection is critical for understanding disease impact.

Purpose of the Study:

  • To assess the fetal consequences of maternal *Toxoplasma gondii* infection occurring around the time of conception.

Main Methods:

  • Retrospective analysis of pregnancies with suspected periconceptional *Toxoplasma gondii* seroconversion over a 10-year period.
  • Definition of periconceptional seroconversion: infection within two months before or after conception.
  • Detailed review of obstetric care, fetal ultrasound findings, and neonatal outcomes.

Main Results:

  • Seventy-nine patients (81 fetuses) met criteria for periconceptional infection.
  • A 3.8% rate of congenital toxoplasmosis was observed.
  • Congenital infections included two late miscarriages (at 15 and 24 weeks) and one infant with subclinical toxoplasmosis.

Conclusions:

  • The observed congenital toxoplasmosis rate (3.8%) slightly exceeds previously reported figures (0.6-3.3%).
  • A high miscarriage rate (66%) was associated with congenital toxoplasmosis.
  • Continuous ultrasound surveillance throughout pregnancy is recommended for optimal fetal care; amniocentesis decisions require careful consideration.