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In vitro skin corrosion: Human skin model test - A validation study
Gajanan Rajpal Deshmukh1, Kuntrapakam Hema Kumar, Poojari Venkata Suresh Reddy
1Aptus Biosciences Private Limited, Yenugonda, Mahabubnagar 509 002, Andhra Pradesh, India.
Summary
This study validates the in vitro skin corrosion human skin model test (OECD 431) as a reliable alternative to animal testing for chemical safety assessments.
Area of Science:
- Toxicology
- Dermatology
- In Vitro Testing
Background:
- The in vivo skin corrosion/irritation test is widely used in India.
- There is a growing need for validated in vitro alternatives to animal testing.
Purpose of the Study:
- To validate the EpiSkinTM in vitro skin corrosion model test.
- To assess its suitability as an alternative to the in vivo test according to OECD Test Guideline 431.
Main Methods:
- Utilized the EpiSkinTM human skin model.
- Tested various corrosive and non-corrosive chemicals as per OECD 431 guidelines.
Main Results:
- The in vitro model accurately predicted the corrosive properties of tested chemicals.
- Results aligned with known skin corrosive classifications.
Conclusions:
- The EpiSkinTM in vitro model is a valid alternative for skin corrosion testing.
- Supports the reduction of animal testing in chemical safety evaluations.
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