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Bone morphogenetic protein-2 will be a novel biochemical marker in urinary tract infections and stone formation
Ragaa H M Salama1, Abdullah Alghasham, Marwa S Mostafa
1Department of Medical Biochemistry, College of Medicine, Qassim University, PO Box 6655, Buraidah 51452, Female Section, Saudi Arabia. ragaa_2002@yahoo.com
Objectives:
To investigate the role of bone morphogenetic protein-2 (BMP-2) in patients with urinary tract infection (UTI) and renal stone in relation to Tamm-Horsfall protein (THP) and osteopontin (OPN).
Design And Methods:
ELISA kits were used to determine these markers in serum and urinary samples of 20 patients with UTI, 15 with renal stone and 10 controls.
Results:
BMP-2 significantly increased in serum of patients who had UTI (P=0.05) and renal stone (P=0.01). In the case of UTI, serum BMP-2 at cutoff 44 pg/mL had sensitivity and specificity (92%, 80%), while cystatin C at cutoff 525 ng/mL showed sensitivity and specificity (85%, 91%). THP is a good predictor of renal diseases (P<0.001) by regression analysis. It is also the most sensitive urinary marker for UTI with sensitivity and specificity (94%, 75%) at cutoff 305 ng/mL.
Conclusion:
Combination of serum BMP-2 and cystatin C are more sensitive and accurate for early diagnosis of renal infection and damage.
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