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Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

Shengtao Zhou1, Linjie Zhao, Manchao Kuang

  • 1Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR China.

Cancer Letters
|May 1, 2012
PubMed

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Cellular Injury V: Apoptosis and Autophagy

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Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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