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Updated: May 22, 2026
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
Published on: January 26, 2015
Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
Eonjeong Park1, Yoon Jung Yang, Aejin Kim
1College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Abstract:
The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 μM, respectively.
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