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Associations between subjective overactive bladder symptoms and objective parameters on bladder diary and filling
N M P Daan1, K J Schweitzer, C H van der Vaart
1Division of Woman & Baby, Department of Urogynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. n.m.p.daan@umcutrecht.nl
International Urogynecology Journal
|May 1, 2012
Summary
Overactive bladder (OAB) frequency and nocturia symptoms correlate well with objective measures. However, urgency symptoms show a weak association, suggesting current OAB trial outcome measures are appropriate.
Area of Science:
- Urogynecology
- Female Pelvic Medicine
- Urology
Background:
- Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and nocturia.
- Objective measures are crucial for validating patient-reported symptoms in OAB research.
Purpose of the Study:
- To assess the associations between different overactive bladder (OAB) symptoms and their objective outcomes.
- To evaluate the correlation of OAB symptoms with bladder diary and filling cystometry parameters.
Main Methods:
- Retrospective cohort study of 6,876 Urinary Distress Inventories, 3,185 bladder diaries, and 2,153 filling cystometries.
- Women were grouped based on the bothersomeness of their OAB symptoms.
- Univariate and multiple linear regression analyses were performed.
Main Results:
- Daytime frequency, nighttime frequency, and incontinence episodes showed significant associations with their respective symptoms.
- Frequency and nocturia symptoms were strongly linked to bladder diary and cystometry filling volumes.
- Urgency symptoms demonstrated a poor association with objective bladder diary and cystometry parameters.
Conclusions:
- Urgency, unlike frequency and nocturia, is poorly correlated with objective urodynamic measures.
- Current OAB trial outcome measures, focusing on frequency and incontinence, are justified.
- Further research may be needed to objectively quantify urgency in OAB.
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