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Updated: May 22, 2026
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Outcome of forced-suction thrombectomy in acute intracranial internal carotid occlusion
Yang-Ha Hwang1, Dong-Hun Kang, Yong-Won Kim
1Department of Neurology, Kyungpook National University Hospital, Daegu, Republic of Korea. yangha.hwang@gmail.com
Insights
The modified Penumbra System (mPS) achieved higher recanalization rates and better functional outcomes for acute distal internal carotid artery (ICA) occlusion compared to mechanical clot disruption (MCD). Successful recanalization independently predicted favorable outcomes.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Surgery
Background:
- Acute distal internal carotid artery (ICA) occlusion often results in poor prognoses despite current intra-arterial revascularization therapies.
- Endovascular techniques are crucial for treating acute ischemic stroke caused by distal ICA occlusion.
Purpose of the Study:
- To compare the efficacy of the modified Penumbra System (mPS) versus mechanical clot disruption (MCD) for acute distal ICA occlusion.
- To evaluate the impact of recanalization on functional outcomes at 3 months post-intervention.
Main Methods:
- A retrospective analysis of 39 patients with acute distal ICA occlusion treated with either MCD (n=19) or mPS (n=20).
- Comparison of recanalization rates and functional outcomes (modified Rankin Scale) at 3 months between the two techniques.
- Univariate and multivariate analyses to identify predictors of favorable functional outcomes.
Main Results:
- The mPS group demonstrated significantly higher successful recanalization rates (85%) compared to the MCD group (32%) (p=0.001).
- Favorable functional outcomes (mRS 0-2) were more frequent in the mPS group (45%) than in the MCD group (16%) (p=0.048).
- Younger age and successful recanalization were identified as independent predictors of favorable outcomes.
Conclusions:
- Forced-suction thrombectomy with the mPS technique appears to be a viable and effective option for acute distal ICA occlusion.
- The mPS technique offers potential for improved recanalization and clinical outcomes in patients with acute distal ICA occlusion.
Objectives:
Ischemic stroke from acute intracranial distal internal carotid artery (ICA) occlusion usually carries a poor prognosis. Despite the intra-arterial revascularization therapies, the results are still unsatisfactory. The aim of this study was to compare the outcomes between two endovascular techniques, the modified Penumbra System (mPS) and mechanical clot disruption (MCD), and to confirm the influence of recanalization on the outcomes.
Methods:
In a retrospective review of 39 consecutive cases of acute distal ICA occlusion, the recanalization rates and functional outcomes at 3 months of the two intra-arterial techniques during two consecutive periods (May 2006 to February 2009: MCD technique (n=19) vs March 2009 to August 2010: mPS technique (n=20)) were compared. Univariate and multivariate analyses were performed to determine the predictors of a favorable functional outcome.
Results:
The rate of successful recanalization (Thrombolysis In Cerebral Infarction score 2 or 3) was significantly higher in the mPS group than in the MCD group (85% (17/20) vs 32% (6/19); p=0.001). Favorable outcomes at 3 months (modified Rankin Scale score 0-2) were achieved in 9/20 and 3/19 in the mPS and MCD groups, respectively (45% vs 16%; p=0.048). Binary logistic regression analysis showed that younger age and successful recanalization were independent predictors of a favorable functional outcome.
Conclusions:
Forced-suction thrombectomy using the mPS technique may be a viable option for acute distal ICA occlusion and could result in more successful recanalization and a more positive clinical outcome.