Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
Overview of Fungi01:29

Overview of Fungi

Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial assessment and scanning electron microscopy analysis of sesquiterpene lactones isolated from the leaves of Inula racemosa Hook. f.

Archives of microbiology·2026
Same author

Unleashing the immune arsenal: development of broad spectrum multiepitope bluetongue vaccine targeting conserved T cell epitopes of structural proteins.

BMC genomics·2026
Same author

Evolving Treatments and Resistance Mechanisms in Prostate Cancer Therapeutics.

ACS pharmacology & translational science·2026
Same author

Deciphering Seedling-Stage Salinity Stress Tolerance in Maize Genotypes Through Morpho-Physiological and Ionic Traits.

International journal of molecular sciences·2026
Same author

Prostate cancer: metabolic remodelling in expressed prostatic secretions reveals cellular structural changes measured by mpMRI.

Molecular omics·2026
Same author

Spin polarized first principles study of electro-magnetic and optical properties of K<sub>2</sub>NaXI<sub>6</sub> (X :Cr Fe) double halide perovskites.

Scientific reports·2026

Related Experiment Video

Updated: May 22, 2026

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

The RAM network in pathogenic fungi.

Sarah Saputo1, Yeissa Chabrier-Rosello, Francis C Luca

  • 1Department of Microbiology/Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Eukaryotic Cell
|May 1, 2012
PubMed
Summary

The regulation of Ace2 and morphogenesis (RAM) network is a crucial signaling pathway in fungi. This study explores its role in yeast and pathogenic fungi, highlighting its importance in fungal biology and disease.

More Related Videos

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy
09:03

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
06:58

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer

Published on: September 29, 2023

Related Experiment Videos

Last Updated: May 22, 2026

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy
09:03

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
06:58

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer

Published on: September 29, 2023

Area of Science:

  • * Molecular Biology
  • * Mycology
  • * Cell Biology

Background:

  • * The Regulation of Ace2 and Morphogenesis (RAM) network is a conserved eukaryotic protein kinase signaling pathway.
  • * In Saccharomyces cerevisiae, the RAM network governs cell cycle, cell separation, mating, growth, and stress responses.
  • * Emerging research indicates the RAM network's significant role in the biology and pathogenesis of fungal species.

Purpose of the Study:

  • * To provide an overview of the RAM network in Saccharomyces cerevisiae.
  • * To summarize recent findings on RAM network function in human fungal pathogens.
  • * To elucidate the importance of the RAM network in fungal pathogenesis.

Main Methods:

  • * Review of existing literature on the RAM network in Saccharomyces cerevisiae.
  • * Synthesis of recent studies focusing on RAM network function in pathogenic fungi.
  • * Comparative analysis of RAM network roles across different fungal species.

Main Results:

  • * The RAM network is essential for various cellular processes in model yeasts.
  • * The RAM network plays a critical role in the virulence and survival of pathogenic fungi.
  • * Functional conservation and divergence of the RAM network are observed across fungal pathogens.

Conclusions:

  • * The RAM network is a key regulator of fungal cell biology and pathogenesis.
  • * Understanding the RAM network in pathogens like Candida albicans and Aspergillus fumigatus is crucial for developing antifungal strategies.
  • * Further research into the RAM network in diverse fungal species will enhance our knowledge of fungal infectious diseases.