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Gender difference in the relation blood pressure-left ventricular mass and geometry in newly diagnosed arterial

Franco Cipollini1, Enrica Arcangeli, Emanuela Greco

  • 1Department of Internal Medicine, Spedali Riuniti, Viale Matteotti 9/D, 51100 Pistoia, Italy.

Blood Pressure
|May 2, 2012
PubMed

Insights

In early hypertension, left ventricular mass (LVM) is linked to daytime blood pressure (BP) in women, while relative wall thickness (RWT) relates to BP in men. LVM changes were more sensitive to BP variations in females.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiovascular Physiology

Background:

  • Sexual dimorphism is observed in the relationship between blood pressure (BP) and left ventricular mass (LVM) in hypertension.
  • Understanding gender-specific BP-LVM associations is crucial for early hypertension management.

Purpose of the Study:

  • To investigate gender-associated differences in the relationship between BP and LVM in newly diagnosed hypertensive individuals.
  • To evaluate how BP parameters relate to LVM indexed and relative wall thickness (RWT).

Main Methods:

  • 209 Caucasian, drug-naïve subjects were studied, with 162 diagnosed with hypertension.
  • Indexed LVM and RWT were measured using echocardiography.
  • 24-hour ambulatory BP monitoring (ABPM) was used to assess BP, including daytime, nighttime, and average values.

Main Results:

  • Daytime systolic BP (SBP) correlated with indexed LVM in females but not males.
  • LVM showed greater sensitivity to BP changes (day-to-night SBP variation) in females.
  • RWT was significantly associated with ABPM values only in males.
  • LVM variance explained by ABPM SBP was substantially higher in females (17%) compared to males (3%).

Conclusions:

  • In early hypertension, LVM is associated with daytime BP and BP variability in females.
  • Concentric LVM remodeling (RWT) is more closely related to BP increase in males.
  • These findings highlight significant gender differences in BP-LVM relationships in early hypertension.

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