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Updated: May 22, 2026
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Influence of Withania somnifera on obsessive compulsive disorder in mice
Bhanu P S Kaurav1, Manish M Wanjari, Amol Chandekar
1Department of Pharmacology, R.K.D.F. College of Pharmacy, Bhopal M.P. India.
Objective:
To study the influence of methanolic and aqueous extract of Withania somnifera (W. somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.
Methods:
Mice were divided in different groups (n = 6). Fluoxetine (5, 10, 15 mg/kg), (10, 25, 50, 100 mg/kg) and methanolic extract W. somnifera (MEWS) (10, 25, 50, 100 mg/kg) were administered i.p. 30 min. prior to the assessment of marble burying behavior and locomotor activity. The control group received vehicle of the extract.
Results:
Administration of aqueous extracts W. somnifera (AEWS) and MEWS (50 mg/kg) successively decreased the marble burying behavior activity without affecting motor activity. This effect of AEWS and MEWS was comparable to standard fluoxetine, ritanserin and parachlorophenylalanine.
Conclusions:
W. somnifera extract is effective in treating obsessive compulsive disorder.
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