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The establishment of an ovum donation program using a simple fixed-dose estrogen-progesterone replacement regimen
A Kogosowski1, I Yovel, J B Lessing
1IVF Unit, Herzliya Medical Center, Herzliya-On-Sea, Israel.
Journal of in Vitro Fertilization and Embryo Transfer : IVF
|October 1, 1990
Summary
This study simplified hormone therapy for ovum donation (OD) recipients, achieving a 61.5% pregnancy rate. The simplified regimen led to successful births in 12 of 21 patients undergoing 26 cycles.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization
- Ovum Donation
Background:
- Traditional ovum donation (OD) protocols require cycle synchronization or complex hormone regimens.
- Previous research suggested a fixed-dose estrogen-progesterone regimen for OD recipients.
- Simplifying existing protocols can improve accessibility and success rates.
Purpose of the Study:
- To evaluate a simplified fixed-dose estrogen-progesterone regimen for ovum donation recipients.
- To assess the efficacy and outcomes of this simplified hormone replacement therapy.
Main Methods:
- Administered 6 mg oral estradiol valerate (E2) daily from day 2-6 of withdrawal bleeding.
- Administered 100 mg intramuscular progesterone (P) daily from 4 days prior to oocyte pickup.
- Performed embryo transfer at the 2-pronuclei (2PN)-10-cell stage.
Main Results:
- 21 patients underwent 26 treatment cycles.
- Achieved 16 pregnancies, with 12 successful births (singleton, twin, and triplet).
- Reported 4 first-trimester miscarriages.
Conclusions:
- The simplified fixed-dose estrogen-progesterone regimen is effective for ovum donation recipients.
- This protocol offers a potentially less complex alternative for hormone replacement in OD.
- Further research may explore optimizing this simplified regimen for improved pregnancy outcomes.