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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

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Related Experiment Video

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Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms
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Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Published on: August 4, 2023

Acinetobacter baumannii: an emerging opportunistic pathogen.

Aoife Howard1, Michael O'Donoghue, Audrey Feeney

  • 1Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.

Virulence
|May 2, 2012
PubMed
Summary
This summary is machine-generated.

Acinetobacter baumannii, a multidrug-resistant (MDR) pathogen, is increasingly causing hospital-acquired infections. This review covers its rise, contributing factors, and new therapeutic strategies for this emerging threat.

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Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms
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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Bacteriology

Background:

  • Acinetobacter baumannii is a significant opportunistic pathogen.
  • It is a primary cause of hospital-acquired infections.
  • Multidrug-resistant (MDR) strains are increasing, particularly in vulnerable populations.

Purpose of the Study:

  • To provide an overview of Acinetobacter baumannii.
  • To discuss factors contributing to its clinical prominence.
  • To outline novel therapeutic strategies under development.

Main Methods:

  • Literature review and synthesis of current research.
  • Analysis of epidemiological trends.
  • Review of emerging treatment modalities.

Main Results:

  • Acinetobacter baumannii infections are rising, especially in healthcare settings.
  • Multidrug resistance is a major challenge in treating these infections.
  • Several novel therapeutic approaches are being investigated.

Conclusions:

  • Acinetobacter baumannii poses a growing threat due to its opportunistic nature and MDR.
  • Understanding the factors driving its prevalence is crucial.
  • Development of new therapies is essential to combat this pathogen.