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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

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Published on: December 3, 2016

Osteochondromatosis in a Rhesus macaque (Macaca mulatta).

Kristin A Matthews¹, Karen Strait, Fawn Connor-Stroud

¹Department of Animal Resources, Yerkes National Primate Research Center, Atlanta, Georgia, USA.

Comparative Medicine

|May 2, 2012

Summary

This study details a rare case of multiple osteochondromas in a rhesus macaque. These benign bone tumors presented as exophytic growths on the femur and tibia.

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Area of Science:

Veterinary Pathology
Primate Medicine
Skeletal Biology

Background:

Osteochondromas are benign cartilage-capped bone tumors that typically occur near growth plates.
Rhesus macaques (Macaca mulatta) are valuable models in biomedical research, and understanding spontaneous conditions is crucial.

Observation:

A 5-year-old male rhesus macaque presented with multiple radiopaque masses on the femur.
Radiographs revealed exophytic masses with mild bony reaction on the proximal tibia.
Histological examination of biopsy tissue showed woven and lamellar bone with granulation tissue.

Findings:

Necropsy confirmed cartilage-capped lesions near the distal femur and midshaft of the femur and tibia.
Histology revealed chondro-osseous exophytic growths consistent with multiple osteochondromas.
The lesions were well-integrated with the host bone, arising near the growth plate.

Implications:

This case highlights the importance of recognizing spontaneous skeletal abnormalities in non-human primates.
Accurate diagnosis of osteochondromas in macaques aids in research study design and animal welfare.
Understanding the presentation and histology of these lesions contributes to comparative pathology knowledge.