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Updated: May 22, 2026
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
Radiotherapy in metastatic ewing sarcoma
Arnold C Paulino1, Wei Y Mai, Bin S Teh
1Department of Radiation Oncology, The Methodist Hospital, Houston, TX 77030, USA. apaulino@tmhs.org
Objective:
To review an institutional experience with radiotherapy (RT) in patients with metastatic Ewing sarcoma.
Methods:
Thirty patients with metastatic Ewing sarcoma were considered. Twenty-nine received multiagent chemotherapy, whereas 22 had local therapy, which included RT in 14, surgery in 5, and surgery followed by RT in 3.
Results:
The 5-year overall survival rate was 22.1%. On multivariate analysis, presence of uncommon sites of metastasis (brain, liver, spleen) (P<0.0001) and use of local therapy to the primary site (P<0.001) were adverse factors for survival. Local control was not achieved in the 8 patients receiving only chemotherapy. All long-term survivors had local therapy including RT to metastatic bony sites and whole-lung irradiation for pulmonary metastasis.
Conclusions:
The presence of uncommon sites of metastasis confers a worse prognosis. Aggressive primary treatment including RT to metastatic sites should be considered in these patients.
