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Published on: December 9, 2016
Radiotherapy in metastatic ewing sarcoma.
Arnold C Paulino1, Wei Y Mai, Bin S Teh
1Department of Radiation Oncology, The Methodist Hospital, Houston, TX 77030, USA. apaulino@tmhs.org
American Journal of Clinical Oncology
|May 2, 2012
Summary
Radiotherapy (RT) combined with aggressive treatment improves survival for metastatic Ewing sarcoma. Local therapy, including RT to metastatic sites, is crucial for long-term survival in these patients.
Area of Science:
- Oncology
- Radiation Oncology
- Pediatric Oncology
Background:
- Metastatic Ewing sarcoma has a poor prognosis.
- Limited data exists on the role of radiotherapy in managing metastatic Ewing sarcoma.
Purpose of the Study:
- To evaluate the institutional experience with radiotherapy in patients diagnosed with metastatic Ewing sarcoma.
- To identify prognostic factors influencing survival in this patient cohort.
Main Methods:
- Retrospective review of 30 patients with metastatic Ewing sarcoma.
- Analysis of treatment modalities including multiagent chemotherapy and local therapies (radiotherapy, surgery).
Main Results:
- The 5-year overall survival rate was 22.1%.
- Uncommon metastatic sites (brain, liver, spleen) and lack of local primary site therapy were associated with worse survival.
- Local control was not achieved with chemotherapy alone; long-term survivors received local therapy including radiotherapy to metastatic bone sites and whole-lung irradiation.
Conclusions:
- Uncommon metastatic sites indicate a poorer prognosis in metastatic Ewing sarcoma.
- Aggressive treatment strategies, incorporating radiotherapy to metastatic sites, should be considered for improved outcomes.
