Related Experiment Video
Updated: May 22, 2026
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Progress and challenges in colorectal cancer screening.
Enrique Quintero1, Cesare Hassan, Carlo Senore
1Gastroenterology Department, Hospital Universitario de Canarias, 38320 La Laguna, Tenerife, Spain.
Gastroenterology Research and Practice
|May 2, 2012
Summary
Technological advancements in fecal and endoscopic screening aim to enhance colorectal cancer detection and reduce mortality. Future strategies will focus on improving participation and cost-effectiveness for better screening program outcomes.
Area of Science:
- Gastroenterology and Oncology
- Public Health and Preventive Medicine
Background:
- Colorectal cancer (CRC) screening via fecal and endoscopic tests reduces incidence and mortality.
- Current screening methods require technological and organizational improvements for better performance and patient acceptance.
Purpose of the Study:
- To review advancements in endoscopic technology for improved neoplasia detection, particularly in the proximal colon.
- To explore new screening strategies combining endoscopic and fecal modalities to boost participation and diagnostic yield.
- To analyze factors influencing the future cost-effectiveness of CRC screening programs.
Main Methods:
- Review of current evidence on long-term efficacy of screening tests.
- Analysis of technological advancements in endoscopic procedures.
- Evaluation of proposed strategies for programmatic screening.
Main Results:
- Ongoing efforts focus on enhancing endoscopic technology to improve neoplasia detection rates.
- New screening strategies integrating fecal and endoscopic approaches are being developed to increase participation.
- The cost-effectiveness of CRC screening is influenced by screening efficacy, participation rates, and treatment costs.
Conclusions:
- Further innovation in screening technologies and strategies is crucial for effective colorectal cancer prevention.
- Improving the performance and acceptability of screening tests will enhance their impact on CRC incidence and mortality.
- Economic factors, including treatment costs, will play a significant role in the future viability of CRC screening programs.
Related Concept Videos
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:25Endoscopic Procedures II: Colonoscopy
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
01:30Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...