Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does This Imaging Make Me Look NFATC2 ? The Value of Radiologic-pathologic Correlation in NFATC2 -rearranged Sarcomas of Bone.

The American journal of surgical pathology·2026

Same author

Characterization and treatment outcomes of malignant histiocytoses in a retrospective series of 141 cases in France.

Blood advances·2025

Same author

MYC Rearrangement Prediction From LYSA Whole Slide Images in Large B-Cell Lymphoma: A Multicentric Validation of Self-supervised Deep Learning Models.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2024

Same author

Baseline circulating tumour DNA and total metabolic tumour volume as early outcome predictors in aggressive large B-cell lymphoma. A real-world 112-patient cohort.

British journal of haematology·2023

Same author

Prevalence of Molecular Alterations in a Swiss Cohort of 512 Colorectal Carcinoma Patients by Targeted Next-Generation Sequencing Analysis in Routine Diagnostics.

Pathobiology : journal of immunopathology, molecular and cellular biology·2022

Same author

Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients.

Clinical & translational immunology·2021

Search research articles

Related Experiment Video

Updated: May 22, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Grey zone lymphomas: lymphomas with intermediate features.

Sylvia Hoeller¹, Christiane Copie-Bergman

¹Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.

Advances in Hematology

|May 2, 2012

Summary

The 2008 World Health Organization classification introduces two new categories for unclassifiable B-cell lymphomas that bridge diagnostic gaps between diffuse large B-cell lymphoma, classical Hodgkin lymphoma, and Burkitt lymphoma.

More Related Videos

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Related Experiment Videos

Last Updated: May 22, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Area of Science:

Hematology
Oncology
Pathology

Background:

Lymphoid neoplasms classification relies on clinical, morphological, immunophenotypic, and molecular data.
Some aggressive B-cell lymphomas present overlapping features, complicating accurate diagnosis.
The 2008 World Health Organization (WHO) classification aimed to address these diagnostic challenges.

Purpose of the Study:

To review the diagnostic criteria for two new provisional categories of unclassifiable B-cell lymphomas.
To discuss emerging scientific findings relevant to these entities within the 2008 WHO classification framework.

Main Methods:

Review of diagnostic criteria for provisional B-cell lymphoma categories.
Discussion of recent scientific advancements impacting classification.

Main Results:

The 2008 WHO classification established provisional categories for B-cell lymphomas intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL).
A second provisional category addresses B-cell lymphomas intermediate between DLBCL and Burkitt lymphoma.
These categories aim to improve classification of challenging aggressive B-cell lymphomas.

Conclusions:

The updated WHO classification provides provisional diagnostic frameworks for difficult-to-classify B-cell lymphomas.
Ongoing research is crucial for refining the understanding and classification of these entities.
Accurate classification is essential for guiding appropriate therapeutic strategies in lymphoid neoplasms.