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Updated: May 22, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
Unilateral hydronephrosis and renal damage after acute leukemia
Egle Simanauskiene1, Valentina Daugelaviciene, Arvydas Laurinavicius
1Children's Hospital, Vilnius University Hospital Santariskiu Klinikos, Santariskiu Street 7, 08406 Vilnius, Lithuania.
Abstract:
A 14-year-old boy presented with asymptomatic right hydronephrosis detected on routine yearly ultrasound examination. Previously, he had at least two normal renal ultrasonograms, 4 years after remission of acute myeloblastic leukemia, treated by AML-BFM-93 protocol. A function of the right kidney and no damage on the left was confirmed by a DMSA scan. Right retroperitoneoscopic nephrectomy revealed 3 renal arteries with the lower pole artery lying on the pelviureteric junction. Histologically chronic tubulointerstitial nephritis was detected. In the pathogenesis of this severe unilateral renal damage, we suspect the exacerbation of deleterious effects of cytostatic therapy on kidneys with intermittent hydronephrosis.
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