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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Adult Sickle Cell Disease: A Five-year Experience of Intensive Care Management in a University Hospital in Oman

Qutaiba Amir Tawfic1, Rajini Kausalya, Dhuha Al-Sajee

  • 1Departments of Anaesthesia & Intensive Care and.

Sultan Qaboos University Medical Journal
|May 2, 2012
PubMed

Insights

Acute chest syndrome is the primary reason for intensive care unit (ICU) admission in sickle cell disease (SCD) patients. Inotropic support or mechanical ventilation indicates a higher mortality risk for these patients.

Area of Science:

  • Hematology
  • Critical Care Medicine
  • Genetics

Background:

  • Sickle cell disease (SCD) is a prevalent inherited hemoglobinopathy in the Gulf region, including Oman.
  • SCD complications frequently necessitate intensive care unit (ICU) admission.
  • Understanding ICU admission drivers is crucial for managing SCD patients.

Purpose of the Study:

  • To investigate the primary causes for ICU admission among adult SCD patients.
  • To identify predictors of mortality in SCD patients admitted to the ICU.

Main Methods:

  • Retrospective analysis of adult SCD patients (≥12 years) admitted to Sultan Qaboos University Hospital ICU.
  • Data collected from January 1, 2005, to December 31, 2009.
  • Analysis included reasons for admission, mortality rates, and impact of supportive measures.

Main Results:

  • 56 ICU admissions occurred among 49 SCD patients.
  • Acute chest syndrome (69.6%) was the leading cause of ICU admission, followed by painful crises (16.1%).
  • Mortality rate was 16.1%; inotropic support and mechanical ventilation significantly predicted mortality.

Conclusions:

  • Acute chest syndrome is the predominant reason for ICU admission in SCD patients.
  • Inotropic support and mechanical ventilation are indicators of increased mortality risk in this population.
  • Non-invasive ventilation, hemofiltration, and transfusions were not significant mortality predictors.
Abstract

Keywords:
Acute chest syndromeAnemiaOmanSickle cell

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