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Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate.
V M Smith1, T Oliphant, M Shareef
1Department of Dermatology, Leeds General Infirmary, Leeds, UK. vanessasmith@doctors.org.uk
Clinical and Experimental Dermatology
|May 3, 2012
Summary
This case study details calciphylaxis, a rare vascular condition, in a patient without kidney failure or hyperparathyroidism. The presentation was linked to trauma, compression, and a Factor V Leiden mutation, successfully treated with sodium thiosulfate.
Area of Science:
- Vascular Medicine
- Dermatology
- Nephrology
Background:
- Calciphylaxis is a rare, severe condition involving arterial calcification and skin infarction.
- It typically occurs in patients with end-stage renal disease or hyperparathyroidism.
Observation:
- A 58-year-old man with asthma on long-term prednisolone and calcium supplementation presented with calciphylaxis.
- He had no history of renal failure or abnormal parathyroid function.
- The condition was potentially triggered by trauma and compression bandaging.
Findings:
- The patient was heterozygous for the Factor V Leiden mutation.
- This represents a unique case of calciphylaxis without common risk factors.
- Intravenous sodium thiosulfate led to a prompt positive response.
Implications:
- Highlights calciphylaxis as a possibility even without typical risk factors like renal failure.
- Suggests potential roles for trauma, compression, and Factor V Leiden in disease precipitation.
- Demonstrates the efficacy of sodium thiosulfate in atypical calciphylaxis cases.
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