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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Developmental Therapeutics Consortium report on study design effects on trial outcomes in chronic myeloid leukaemia

Francis Giles1, François-Xavier Mahon, Bjorn Gjertsen

  • 1HRB Clinical Research Facility, National University of Ireland Galway and Trinity College Dublin, Dublin, Ireland. frankgiles@aol.com

European Journal of Clinical Investigation
|May 3, 2012
PubMed
Abstract

Insights

Nilotinib and dasatinib offer improved responses in chronic myeloid leukaemia (CML) compared to imatinib. This review compares ENESTnd and DASISION trials to aid physicians in selecting optimal frontline CML treatments.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukaemia (CML) treatment.
  • Phase 3 trials (ENESTnd, DASISION) show nilotinib and dasatinib improve responses over imatinib in newly diagnosed CML patients.

Purpose of the Study:

  • To provide a comparative analysis of the ENESTnd and DASISION trial designs and reported data.
  • To assist physicians in making informed decisions for frontline CML treatment.

Main Methods:

  • Systematic literature review by the Developmental Therapeutics Consortium (DTC).
  • Comparative analysis of ENESTnd and DASISION trial designs and outcomes.

Main Results:

  • Nilotinib and dasatinib offer effective frontline CML treatment options.
  • Physicians can optimize treatment based on patient comorbidities, risk factors, and tolerability.

Conclusions:

  • Direct comparison of nilotinib and dasatinib is challenging due to study design and population differences.
  • This DTC report summarizes trial data to aid physician decision-making for CML therapy.

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