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Trigoflavidols A-C, degraded diterpenoids with antimicrobial activity, from Trigonostemon flavidus
Gui-Hua Tang1, Yu Zhang, Yu-Cheng Gu
1State Key Laboratory of Phytochemistry and Plant Resources in West China, People's Republic of China.
Abstract:
Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12-6.25 μg/mL) against Staphylococcus aureus, 8(#)MRSA, and 82(#)MRSA, and 1, 2, and 5 showed weak activities (IC(50) values: 3.75-28.99 μM) against various human tumor cell lines.
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