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Updated: May 22, 2026
10:10
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Tuberculous meningitis in a lung transplanted patient
N E Hiemann1, S Grimmer, D Kemper
1Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany. hiemann@dhzb.de
Summary
Tuberculosis can occur in lung transplant patients with quadruple immunosuppression. Prompt diagnosis and treatment of tuberculous meningitis led to complete neurological recovery.
Area of Science:
- Nephrology
- Immunology
- Infectious Diseases
Background:
- Lung transplant recipients require immunosuppression to prevent organ rejection.
- Quadruple maintenance immunosuppression regimens increase the risk of opportunistic infections.
Observation:
- A 57-year-old female lung transplant recipient presented with respiratory compromise and acute cellular rejection.
- The patient developed a deteriorating neurological status.
- Cerebral imaging and lumbar puncture confirmed Mycobacterium tuberculosis.
Findings:
- The patient was diagnosed with tuberculous meningitis and elevated intracranial pressure.
- Treatment involved 2 weeks on a neurosurgical ward and 2 weeks of intensive care.
- Complete neurological recovery was achieved within 3 months.
Implications:
- This case highlights the risk of tuberculosis in heavily immunosuppressed lung transplant patients.
- Early recognition and aggressive management are crucial for favorable outcomes in tuberculous meningitis.
- Optimizing immunosuppression strategies may help reduce infection risks in transplant recipients.
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