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Updated: May 22, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Changes in neurocognitive functioning following lung transplantation.

B M Hoffman1, J A Blumenthal, R C Carney

  • 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. benson.hoffman@duke.edu

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 3, 2012
PubMed
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Lung transplantation may lead to cognitive decline in older patients, impacting daily function. While verbal memory improved slightly, executive function worsened in older individuals post-transplant.

Area of Science:

  • Pulmonary Medicine
  • Neuroscience
  • Transplantation Surgery

Background:

  • Neurocognitive impairment is common in advanced lung disease.
  • Limited data exists on neurocognitive changes after lung transplantation.

Purpose of the Study:

  • To assess neurocognitive changes before and after lung transplantation.
  • To identify predictors of neurocognitive change post-transplant.

Main Methods:

  • Administered 10 neurocognitive tests to 49 lung transplant recipients.
  • Evaluated cognitive function at baseline and 6 months post-transplant.
  • Analyzed changes in executive function and verbal memory.

Main Results:

  • Verbal memory scores slightly improved post-transplant.

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  • Executive function improved in younger patients but declined in older patients.
  • 29% of patients showed significant cognitive decline, particularly older, less educated individuals.

    • Conclusions:

    • Lung transplantation is associated with cognitive decline in a subset of older patients.
    • Cognitive decline post-transplant may affect daily functioning.
    • Age and education level are potential predictors of cognitive change.