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Lipid fingerprinting in women with early-onset preeclampsia: a first look
Leandro De Oliveira1, Niels Olsen S Câmara, Tatiana Bonetti
1Obstetrics Department, Universidade Federal de São Paulo, Brazil. Leminas@ig.com.br
Objectives:
The aim of this preliminary study was to characterize the plasma lipid profiling of women with preeclampsia.
Design And Methods:
Plasma samples of 8 pregnant women with early-onset preeclampsia and 8 normal pregnant women were evaluated. Lipids were extracted from plasma using the Bligh-Dyer protocol. The extracts were subjected to MALDI-MS. Data matrix was exported for partial least squares discriminant analysis (PLS-DA) and a parameter VIP was employed to reflect the variable importance in the discriminant analysis. The major discriminant variables were selected and underwent to Mann-Whitney U test.
Results:
A total of 1290 ions were initially identified and twelve m/z signals were highlighted as the most important lipids for the discrimination of patients with preeclampsia. The identification of these differential lipids was carried out through Lipid Database Search.
Conclusions:
The main classes identified were glycerophosphocholines [GP01], glycerophosphoserines [GP03], glycerophosphoglycerols [GP04], glycosyldiradylglycerols [GL05] and glycerophosphates [GP10].
