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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: May 22, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

[Epigenetic regulation during osteoclastogenesis].

Min Young Youn1, Shigeaki Kato, Yuuki Imai

  • 1Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.

Clinical Calcium
|May 3, 2012
PubMed
Summary
This summary is machine-generated.

This study identifies novel epigenetic regulators crucial for osteoclast differentiation and maturation. These findings enhance our understanding of epigenetic control in osteoclastogenesis.

More Related Videos

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow
11:11

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Published on: May 19, 2019

Related Experiment Videos

Last Updated: May 22, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow
11:11

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Published on: May 19, 2019

Area of Science:

  • Cell Biology
  • Epigenetics
  • Hematopoiesis

Context:

  • Osteoclasts, multinucleated cells derived from hematopoietic stem cells, are essential for bone remodeling.
  • Transcription factors orchestrate gene networks during osteoclastogenesis.
  • Epigenetic regulators, including histone modifiers and chromatin remodelers, are increasingly recognized as critical for gene regulation.

Purpose:

  • To identify novel epigenetic regulators involved in osteoclastogenesis.
  • To investigate the role of these regulators in controlling NFATc1 function.
  • To elucidate new epigenetic mechanisms governing osteoclast maturation.

Summary:

  • This research focused on uncovering new epigenetic regulators essential for osteoclast differentiation and maturation.
  • Biochemical approaches were employed to identify these regulators and understand their role in fine-tuning NFATc1 activity.
  • The study highlights a novel epigenetic regulation mechanism critical for normal osteoclastogenesis.

Impact:

  • Provides new insights into the epigenetic control of osteoclast differentiation.
  • Identifies key epigenetic regulators necessary for osteoclast maturation.
  • Offers potential targets for therapeutic interventions related to bone diseases involving osteoclast dysfunction.