[Genome-wide approaches for clarification of androgen receptor function]

Androgen and estrogen are sex steroid hormones, which bind to it own nuclear receptors, such as androgen receptor (AR) and estrogen (ER) , and exert its action through regulation of target gene expressions, and contribute to the maintenance of various homeostasis. However, the mode of binding of AR and ER binding site on the genome DNA and their intracellular behavior are diverse in various cells. From genome-wide analysis studies with the advent and remarkable development of next-generation sequencer in recent years, it has been clarified that new features and mechanism of action of sex hormone receptors in breast cancer and prostate cancer. In this paper, we focus on the AR, together with recent findings on genome-wide analysis, and we also introduce the current application for bone metabolism.