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Metabolic regulation is important for spermatogenesis.

Luís Rato¹, Marco G Alves, Sílvia Socorro

¹Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior (CICS-UBI), 6201-506 Covilhã, Portugal.

Nature Reviews. Urology

|May 3, 2012

Summary

Sertoli cells support sperm development by metabolizing glucose into lactate, which fuels germ cells and prevents their death. This process is influenced by sex hormones and overall energy status, impacting male fertility.

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Area of Science:

Reproductive Biology
Cell Metabolism
Infertility Research

Background:

Male factor infertility is rising globally, linked to lifestyle impacts on spermatogenesis.
Sertoli cells are crucial for germ cell development, providing metabolic support.
Sertoli cells exhibit unique metabolism, favoring glucose conversion to lactate over oxidation.

Purpose of the Study:

To elucidate the mechanisms of lactate secretion by Sertoli cells.
To understand the role of lactate as an energy substrate and antiapoptotic factor for germ cells.
To investigate the influence of sex steroid hormones on Sertoli cell metabolism and male reproductive function.

Main Methods:

Analysis of glucose transport via glucose transporters.
Assessment of lactate dehydrogenase activity in pyruvate to lactate conversion.
Investigation of monocarboxylate transporters in lactate release.
Examination of sex steroid hormone effects on Sertoli cell metabolism.

Main Results:

Lactate, derived from glucose, is the primary energy source for developing germ cells.
Lactate exhibits antiapoptotic effects on germ cells.
Sertoli cell metabolism, including lactate secretion, is modulated by sex steroid hormones.
Reproductive function is sensitive to metabolic cues and energy homeostasis.

Conclusions:

Sertoli cells play a vital role in male fertility through metabolic support of germ cells via lactate.
Sex steroid hormones are key regulators of Sertoli cell metabolism, influencing male reproductive health.
Understanding Sertoli cell metabolism offers potential therapeutic targets for male infertility.