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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

A stimuli-sensitive injectable graphene oxide composite hydrogel.

Abhishek Sahu1, Won Il Choi, Giyoong Tae

  • 1School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.

Chemical Communications (Cambridge, England)
|May 3, 2012
PubMed
Summary

Researchers created a self-assembling graphene oxide hydrogel that transitions between liquid and gel states with temperature, light, or pH changes. This injectable material shows promise for biomedical applications due to its stability and low toxicity.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Graphene oxide (GO) nanosheets are promising nanomaterials with unique properties.
  • Developing injectable hydrogels with tunable properties is crucial for advanced biomedical applications.

Purpose of the Study:

  • To develop a self-assembled hydrogel of graphene oxide nanosheets without chemical modification.
  • To investigate the stimuli-responsive sol-gel transition of the GO hydrogel.
  • To evaluate the potential of this hydrogel as an injectable system for in vivo applications.

Main Methods:

  • Physically crosslinking graphene oxide nanosheets in a low concentration Pluronic solution.
  • Investigating sol-gel transitions induced by temperature, near-infrared (NIR) light, and pH.
  • Conducting in vivo mouse experiments to assess injectability and cytotoxicity.

Main Results:

  • A self-assembled graphene oxide hydrogel was successfully formed via physical crosslinking.
  • The hydrogel exhibited a reversible sol-gel transition in response to temperature, NIR light, and pH.
  • Thermosensitive gelation near body temperature and rapid gelation via photothermal effect were observed.
  • In vivo studies confirmed stable gel formation after injection with no significant acute cytotoxicity.

Conclusions:

  • The developed graphene oxide hydrogel is a stimuli-responsive material suitable for injectable applications.
  • The absence of chemical modification simplifies the fabrication process.
  • The material demonstrates good biocompatibility, paving the way for its use in regenerative medicine and drug delivery.