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Biliary and gut function following shock.

F G Moody1, R Calabuig, Y F Li

  • 1Department of Surgery, University of Texas Medical School, Houston 77030.

The Journal of Trauma
|December 1, 1990
PubMed
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Hemorrhagic shock and blood reperfusion significantly impair gallbladder and intestinal motility. These digestive function alterations, observed early after injury, suggest a mechanism of ischemia-hypoxia.

Area of Science:

  • Physiology
  • Gastroenterology
  • Trauma Research

Background:

  • Hemorrhagic shock and subsequent blood reperfusion are critical insults.
  • Understanding their impact on digestive system function is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the functional changes in the gallbladder and intestines following hemorrhagic shock and reperfusion.
  • To elucidate the temporal pattern of these functional alterations and their underlying mechanisms.

Main Methods:

  • Opossums underwent induced hemorrhagic shock (30 mm Hg for 60 minutes) followed by blood resuscitation.
  • Evaluated gallbladder epithelial ion transport, motility (in vitro and in vivo), gastrointestinal motility, and gut flora at 2 and 24 hours post-shock.

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Main Results:

  • Early (2 hours) decreases in gallbladder contractility and emptying, uncoordinated motor activity, reduced intestinal slow wave frequency, and shorter migrating motor complex cycles were observed.
  • By 24 hours, increased gallbladder epithelial permeability and persistent reduced in vitro contractility were noted, with partial recovery of in vivo functions. Gastrointestinal flora remained unaffected.

Conclusions:

  • Hemorrhagic shock and reperfusion induce significant alterations in digestive motility.
  • The rapid onset and partial recovery suggest ischemia-hypoxia as the primary injury mechanism affecting the gallbladder and intestines.