Jove
Visualize
Contact Us

Related Experiment Videos

Antibiotics and the postburn hypermetabolic response.

J P Waymack1

  • 1Library Branch, U.S. Army Institute of Surgical Research, Fort Sam Houston, TX 78234.

The Journal of Trauma
|December 1, 1990
PubMed
Summary

Severe burn injuries increase metabolic energy expenditure, potentially due to bacterial infections. Topical antimicrobials may reduce this hypermetabolic response in burn patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Academic surgeons' knowledge of Food and Drug Administration regulations for clinical trials.

Archives of surgery (Chicago, Ill. : 1960)·1997
Same author

Trauma, shock, and gut translocation.

New horizons (Baltimore, Md.)·1996
Same author

A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients.

The Journal of trauma·1995
Same author

Recent advances in burn care.

Annals of the New York Academy of Sciences·1994
Same author

Effect of PGE in multiple experimental models. IX: In vivo effects of PGE on immune response of leucocytes to wounds.

Burns : journal of the International Society for Burn Injuries·1994
Same author

Effect of ibuprofen on the inflammatory response to surgical wounds.

The Journal of trauma·1993
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Metabolic response to injury
  • Burn wound infections
  • Microbial translocation

Background:

  • Severe burn injuries significantly elevate resting metabolic energy expenditure.
  • This hypermetabolic state is potentially linked to bacterial colonization and infection of burn wounds.

Purpose of the Study:

  • To investigate the correlation between burn wound bacterial colonization and metabolic alterations.
  • To evaluate the efficacy of topical antimicrobial agents in mitigating post-burn hypermetabolism.
  • To assess the role of burn-induced intestinal bacterial translocation in the hypermetabolic response.

Main Methods:

  • Correlation analysis between burn wound bacterial load and metabolic rate.
  • Administration of topical antimicrobial agents to assess impact on metabolic demands.
  • Evaluation of selective digestive tract decontamination using enteral antibiotics in a burned guinea pig model.

Main Results:

  • Topical antimicrobial use was associated with decreased metabolic alterations in burn patients.
  • Selective decontamination of the digestive tract in a guinea pig model did not significantly affect the hypermetabolic response.

Conclusions:

  • Topical antibacterial agents may be beneficial in reducing metabolic demands in burn patients.
  • Intestinal bacterial translocation may not be a primary driver of the postburn hypermetabolic response, or current methods of prevention are ineffective.

Related Experiment Videos