In vivo delivery of plasmid DNA into rabbit myocardium using polylysine copolymers

The terplex system for delivering DNA to targeted cells comprises three components-stearyl polylysine (PLL), low-density lipoprotein (LDL), and DNA. This article describes the use of a terplex complex to deliver plasmid DNA carrying the vascular endothelial growth factor VEGF165 into rabbit myocardium. Transfection with VEGF is assessed by comparing tissue pathology and pumping function of the heart in control and experimental animals after induced myocardial infarction.