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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: May 22, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

Oncogenomics methods and resources.

Simon J Furney, Gunes Gundem, Nuria Lopez-Bigas

    Cold Spring Harbor Protocols
    |May 3, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Cancer is a genetic disease driven by inherited and somatic genetic alterations. This review covers genomic changes, transcriptomic impacts, and data analysis methods in cancer research.

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    Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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    Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

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    Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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    Published on: May 17, 2019

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    Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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    Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

    Published on: October 11, 2019

    Area of Science:

    • Oncology
    • Genetics
    • Genomics

    Background:

    • Cancer is understood as a genetic disease involving oncogenesis.
    • Cancer development is a multi-year process driven by genetic factors.
    • Uncontrolled cell growth and mortality are hallmarks of cancer progression.

    Purpose of the Study:

    • To review genomic and genetic alterations in cancer.
    • To discuss transcriptomic consequences of these alterations.
    • To describe next-generation sequencing methods and data analysis approaches.

    Main Methods:

    • Review of genomic alterations: copy-number changes, rearrangements, somatic mutations, polymorphisms, and epigenomic alterations.
    • Analysis of transcriptomic consequences in tumor cells.
    • Description of next-generation sequencing (NGS) applications in cancer research.

    Main Results:

    • Identified key genomic alterations driving cancer.
    • Detailed transcriptomic impacts of genetic changes.
    • Highlighted the role of NGS in cancer research.

    Conclusions:

    • Understanding cancer's genetic basis is crucial.
    • Genomic alterations and their transcriptomic effects are central to oncogenesis.
    • Advanced sequencing and data analysis are vital for cancer research.