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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 22, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Proteomic technologies for the study of osteosarcoma.

Stephanie D Byrum¹, Charity L Washam, Corey O Montgomery

¹Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.

|May 3, 2012

Summary

This study explores proteomic technologies to find new diagnostic and therapeutic targets for osteosarcoma, a common childhood bone cancer. Understanding these targets is crucial for developing effective treatments for osteosarcoma.

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Last Updated: May 22, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Published on: April 12, 2019

Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment

Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment

Published on: June 3, 2022

Area of Science:

Oncology
Proteomics
Molecular Biology

Background:

Osteosarcoma is the most frequent primary bone cancer in children, arising during rapid bone growth.
It results from immature osteoblast differentiation, leading to abnormal bone matrix formation.
The mechanisms of osteosarcoma tumorigenesis remain poorly understood, with limited proteomic investigation.

Purpose of the Study:

To review state-of-the-art proteomic technologies for discovering novel osteosarcoma diagnostic and therapeutic targets.
To describe current signaling markers and pathways associated with primary and metastatic osteosarcoma identified through proteomic studies.

Main Methods:

Focus on the application of advanced proteomic technologies.
Review of existing literature on proteomic studies in osteosarcoma.
Analysis of identified signaling markers and pathways.

Main Results:

Previous proteomic studies identified proteins associated with general malignancies, not osteosarcoma-specific ones.
Emerging proteomic technologies offer potential for discovering novel osteosarcoma targets.
Key signaling markers and pathways in osteosarcoma have been identified.

Conclusions:

Advanced proteomic technologies are essential for identifying specific osteosarcoma biomarkers.
Further proteomic research is needed to elucidate osteosarcoma pathogenesis and discover targeted therapies.
This review highlights the potential of proteomics in advancing osteosarcoma diagnosis and treatment.