Related Experiment Video

Updated: May 22, 2026

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

[Coronary revascularization versus optimal medical therapy in elderly patients with stable multivessel disease]

A A Bogachev, K L Kozlov, I B Oleksiuk

    Advances in Gerontology = Uspekhi Gerontologii
    |May 4, 2012
    PubMed

    Insights

    Elderly patients with stable angina and multivessel coronary disease benefit more from revascularization compared to optimal medical therapy alone. A heart team approach is crucial for personalized treatment decisions.

    Area of Science:

    • Cardiology
    • Geriatric Medicine
    • Interventional Cardiology

    Context:

    • Multivessel coronary artery disease (CAD) is prevalent in the elderly population.
    • Stable angina management in older adults presents complex treatment choices.
    • Optimal medical therapy (OMT) versus revascularization strategies require careful consideration.

    Purpose:

    • To evaluate the optimal primary treatment strategy for elderly patients with stable angina and multivessel CAD.
    • To compare the benefits of revascularization (percutaneous coronary intervention or coronary artery bypass grafting) plus OMT versus OMT alone in this demographic.
    • To highlight the importance of a multidisciplinary heart team approach in decision-making.

    Summary:

    • Clinical trials indicate that elderly patients with multivessel CAD experience greater benefits from revascularization compared to younger individuals.
    • Revascularization, combined with OMT, offers improved outcomes for older adults with stable angina.
    • Age alone is insufficient to dictate treatment; comprehensive patient factors are essential.

    Impact:

    • Informs clinical guidelines for managing stable angina in elderly patients with multivessel CAD.
    • Emphasizes the value of personalized treatment strategies tailored by a heart team.
    • Promotes shared decision-making between clinicians and patients regarding revascularization options.

    Related Concept Videos

    Coronary Artery Disease V: Interprofessional Care01:27

    Coronary Artery Disease V: Interprofessional Care

    Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    Angina IV: Management01:26

    Angina IV: Management

    IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
    Mitral Stenosis III: Medical Management01:26

    Mitral Stenosis III: Medical Management

    Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
    Rheumatic Heart Disease III: Medical Management01:21

    Rheumatic Heart Disease III: Medical Management

    Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
    Atherosclerosis III: Management01:26

    Atherosclerosis III: Management

    Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...