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[Cell fusion as a key mechanism for cell-based therapy towards Duchenne muscular dystrophy]

Akihiro Umezawa1, Yayoi Kawamichi, Kayoko Saito

  • 1Center for Regenerative Medicine, National Rsearch Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

Seikagaku. the Journal of Japanese Biochemical Society
|May 4, 2012
PubMed
Abstract

No abstract available in PubMed .

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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