Choriocarcinoma with brain metastasis: report on two cases with long-term survivals

Choriocarcinoma is a potentially curable neoplasm. Although the presence of brain metastases worsens the ultimate prognosis, aggressive therapeutic intervention is sometimes justified for brain metastases of a potentially curable neoplasm. In the present clinical report, we present two cases of choriocarcinoma with brain metastasis manifesting neurological deterioration, and discuss treatment strategies. From the results of treatment, we conclude that surgical removal of the lesion, followed by chemotherapy combined with irradiation, should be the treatment of choice in patients with progressive neurological deterioration.