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Primary pleomorphic liposarcoma of the orbit: a case report
Madeline Doyle1, Alexandre N Odashiro, Patrícia R Pereira
1Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, Quebec, Canada.
Orbit (Amsterdam, Netherlands)
|May 4, 2012
Summary
Pleomorphic liposarcoma (PL) of the orbit is rare, posing diagnostic and treatment challenges. This case highlights a patient who refused standard treatment but remained recurrence-free for two years.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Pleomorphic liposarcoma (PL) is a rare orbital malignancy.
- Limited case reports exist, complicating diagnosis and treatment strategies.
Observation:
- A 62-year-old female presented with orbital symptoms including pruritus, edema, proptosis, and diplopia.
- Imaging identified an intraorbital mass with sinus infiltration.
- Histological examination revealed a highly cellular, heterogeneous tumor with malignant features.
Findings:
- Immunohistochemistry confirmed pleomorphic liposarcoma (PL) of the orbit, with S-100 positivity.
- Despite a generally poor prognosis associated with PL, the patient refused recommended exenteration and radiation therapy.
Implications:
- This case suggests that even without aggressive treatment, long-term remission may be possible for orbital pleomorphic liposarcoma (PL).
- Further research is needed to understand prognostic factors and optimal management for this rare orbital tumor.