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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Updated: May 22, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[An infant with blisters post partum].

Anke Nijkamp1, Daniëlle S J van Bommel-Slee

  • 1Ziekenhuisgroep Twente, afd. Kindergeneeskunde, Almelo, the Netherlands. anke.nijkamp@gmail.com

Nederlands Tijdschrift Voor Geneeskunde
|May 4, 2012
PubMed
Summary
This summary is machine-generated.

A newborn presented with pre-auricular vesicles, initially suspected as friction or impetigo bullosa. Diagnosis was revised to focal pre-auricular dermal dysplasia after antibiotic treatment failed.

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Area of Science:

  • Dermatology
  • Pediatrics
  • Medical Genetics

Background:

  • Congenital anomalies require prompt diagnosis and management.
  • Pre-auricular lesions in newborns can have various etiologies.
  • Dermal dysplasias represent a group of developmental abnormalities affecting the skin.

Observation:

  • A newborn male infant presented with bilateral pre-auricular vesicles shortly after birth.
  • No other congenital abnormalities were noted in the infant.
  • The vesicular lesions on the cheeks were unresponsive to topical antibiotic treatment.

Findings:

  • Initial differential diagnoses included friction injury and bullous impetigo.
  • Failure of antibiotic therapy suggested a non-infectious etiology.
  • After one month, the clinical presentation led to the postulation of focal pre-auricular dermal dysplasia.

Implications:

  • Focal pre-auricular dermal dysplasia should be considered in the differential diagnosis of neonatal cheek vesicles.
  • This case highlights the importance of considering rare developmental conditions.
  • Further investigation may be warranted to understand the pathogenesis and long-term outcomes of this condition.