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Updated: May 22, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Plaque attack: one hundred years of atherosclerosis in The American Journal of Pathology
Martha B Furie1, Richard N Mitchell
1Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA. Martha.Furie@stonybrook.edu
Abstract:
Research articles on atherosclerosis have been well represented in The American Journal of Pathology (AJP), with more than 500 articles published since 1925. An initial focus on descriptive studies led to the proposal that atherosclerosis occurs as a response to vascular injury. With time, this view was modified by a greater understanding of the roles played by lipids and integrity of the vessel wall's constituent cells and matrix. AJP has been a major contributor to the field, publishing numerous seminal research papers and review articles on the latest advances in atherosclerosis. This Centennial Review highlights these myriad contributions.
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