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Updated: May 22, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
[Fulminant lobulated lung empyema caused by Pseudomonas aeruginosa]
Hsuan-Wei Chen1, Jing-Quan Zheng, Te-Yu Lin
1Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
Abstract:
We report the case of a 27-year-old man with a history of diabetes mellitus who presented with conscious disturbance, fever, and stiff neck after upper respiratory tract infection. Following diagnosis of meningoencephalitis, antibiotic therapy and deamethasone was initiated. He received endotracheal tube intervention under mechanical ventilation in the intensive care unit, and underwent successful weaning on day 4. One week later, he was diagnosed with pneumonia and a rapidly progressing lung empyema with abscess formation was noted. Microbiological culture of the pleural fluid revealed the presence of Pseudomonas aeruginosa. Nosocomial pneumonia is often caused by Staphylococcus aureus and P. aeruginosa; however, the latter often causes bronchopneumonia rather than fulminant empyema or lung abscess formation. The underlying diabetes mellitus and the history of steroid therapy may explain the present condition of this patient. The possibility of P. aeruginosa being the causative agent should be considered during differential diagnosis in patients presenting with fulminant lung empyema, especially in immunocompromised patients.
Insights
A young man with diabetes developed severe meningoencephalitis and later Pseudomonas aeruginosa-induced lung empyema. This case highlights P. aeruginosa as a rare but critical cause of severe lung infections, especially in immunocompromised individuals.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Pulmonology
Background:
- A 27-year-old male with diabetes mellitus presented with symptoms of meningoencephalitis following an upper respiratory tract infection.
- Initial treatment included antibiotics and dexamethasone, with mechanical ventilation required for respiratory support.
Observation:
- The patient developed severe pneumonia with rapidly progressing lung empyema and abscess formation.
- Pleural fluid cultures identified Pseudomonas aeruginosa as the causative pathogen.
Findings:
- Pseudomonas aeruginosa, typically causing bronchopneumonia, was found to be responsible for fulminant empyema and lung abscess in this case.
- The patient's underlying diabetes mellitus and prior steroid therapy likely contributed to the severity and progression of the infection.
Implications:
- This case underscores the importance of considering Pseudomonas aeruginosa in the differential diagnosis of severe, rapidly progressing lung empyema.
- Immunocompromised patients, particularly those with diabetes or on steroid therapy, are at higher risk for unusual and severe presentations of P. aeruginosa infections.
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