Related Experiment Video

Updated: May 22, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

Intima media thickness in children undergoing dialysis

Luis Antonio Chavarria1, Alejandra Aguilar-Kitsu, Patricia Rosas

  • 1Departamento de Nefrologia, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.

Pediatric Nephrology (Berlin, Germany)
|May 4, 2012
PubMed

Insights

Vascular calcification is common in children on dialysis, increasing with time. Hemodialysis (HD) is linked to increased vascular issues compared to peritoneal dialysis (PD), highlighting the need for monitoring.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in Chronic Kidney Disease (CKD)

Background:

  • Uremic vasculopathy and vascular calcification are significant risks for cardiovascular disease and mortality in CKD patients.
  • Investigated prevalence and factors associated with vasculopathy in pediatric patients undergoing dialysis.

Purpose of the Study:

  • To determine the prevalence of vasculopathy in children on peritoneal dialysis (PD) or hemodialysis (HD).
  • To identify factors associated with vasculopathy in pediatric dialysis patients.

Main Methods:

  • Assessed common carotid intima media thickness (cIMT) in 60 pediatric patients (mean age 12.9 years) on PD or HD.
  • Analyzed cIMT in relation to demographics, biochemical parameters, and medication, dividing patients into normal and increased cIMT groups.

Main Results:

  • Increased cIMT (29 patients) was associated with longer dialysis duration (>2 years), hypercalcemia, higher calcitriol dose, and hemodialysis (HD) compared to peritoneal dialysis (PD).
  • Multivariate analysis confirmed HD as an independent risk factor for increased cIMT, even after accounting for dialysis duration.

Conclusions:

  • Increased cIMT prevalence in pediatric dialysis patients is similar to adults and rises with dialysis duration.
  • HD is associated with increased cIMT independently of time on dialysis, suggesting a need for monitoring and intervention in pediatric dialysis patients.
Abstract

More Related Videos

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...